GLP-1 Injection Safety Information

Your provider has prescribed a GLP-1 medication to support your weight-management plan. Please review the safety information below to understand how this treatment works, what to expect, and when to seek medical attention.

You may receive a compounded version of semaglutide if your clinician determines it is medically appropriate. Compounded semaglutide is not approved or reviewed by the U.S. Food and Drug Administration (FDA) for safety or effectiveness.

How This Medication Works

Compounded semaglutide is a GLP-1 receptor agonist used alongside healthy eating and increased physical activity to support chronic weight management in adults with a BMI of 27 kg/m² or higher.

It is not recommended to use this medication alongside other GLP-1 products or semaglutide-containing medications. The safety of combining this medication with other weight-management treatments has not been established.

Common Side Effects

Many patients experience mild gastrointestinal symptoms as their body adjusts. These often improve over time.

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal discomfort
• Indigestion or bloating
• Headache
• Fatigue
• Dizziness

If symptoms are persistent or severe, contact your provider.

Important Safety Information

Thyroid C-Cell Tumor Risk (Animal Data)

In animal studies, semaglutide has been associated with an increased risk of thyroid C-cell tumors. It is not known whether this applies to humans.

Do not use this medication if you or a family member has:

• Medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Tell your provider right away if you notice symptoms such as a lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath.

Do Not Use This Medication If You:

• Have a personal or family history of MTC or MEN2
• Have Type 1 or Type 2 diabetes
• Have a history of pancreatitis
• Have gastroparesis or any condition that slows stomach emptying
• Have a known allergy to semaglutide, GLP-1 medications, or formulation ingredients
• Have a history of suicidal behavior or active suicidal ideation

Warnings & Precautions

Pancreatitis

Cases have occurred in patients using GLP-1 medications. If you experience severe or persistent abdominal pain, seek medical attention immediately.

Gallbladder Issues

Gallstones and gallbladder inflammation have been reported. Notify your provider if you develop abdominal pain, fever, or jaundice.

Delayed Stomach Emptying

GLP-1 medications slow digestion. Individuals with existing stomach issues may notice worsening symptoms.

Hypoglycemia

Using this medication with insulin or insulin-stimulating drugs may increase the risk of low blood sugar. Know the symptoms: sweating, shakiness, headache, dizziness, and confusion.

Kidney Function

Dehydration due to vomiting or diarrhea may contribute to kidney problems. Stay hydrated and monitor symptoms closely.

Hypersensitivity Reactions

Stop the medication and seek medical care if you develop swelling, rash, difficulty breathing, or signs of an allergic reaction.

Pregnancy and Fertility

This medication should be discontinued at least 2 months before a planned pregnancy. Stop treatment immediately if you become pregnant.

Mood Monitoring

Inform your provider if you experience new or worsening depression, mood changes, or suicidal thoughts.

Heart Rate Changes

Your provider may periodically monitor your resting heart rate.

Vision Health

Recent research has explored a potential association between semaglutide and a rare eye condition (NAION). This link has not been proven. Discuss any vision changes with your provider.

Additional Side Effects

Other reported side effects include:

• Gas or abdominal bloating
• Acid reflux
• Mild gastrointestinal illness
• Nasal congestion or sore throat
• General flu-like symptoms

Drug Interactions

Semaglutide slows gastric emptying, which may affect how other oral medications are absorbed. Inform your provider about all prescription medications, over-the-counter drugs, and supplements you use.

When to Seek Medical Attention

Contact your healthcare provider promptly if you experience:

• Severe abdominal pain
• Persistent vomiting
• Signs of dehydration
• Sudden vision changes
• Difficulty breathing or severe allergic reactions
• Any concerning or unusual symptoms